The design of the keyboard in the Microsoft Natural Ergonomic Desktop 7000 is essentially the same as the Microsoft Natural Ergonomic Keyboard 4000, though the former connects to your computer wirelessly via a USB receiver. These weren't enough to outweigh the other comfort benefits of the set's design for our moderately achy wrists, but they could very well be deal-breakers for those with more serious injuries. Our only gripes come from resistance: The keys feel just a bit too stiff, and the mouse scroll button requires just a bit too much force. We used the Natural Ergonomic Desktop 7000 with our primary computer for several weeks, and we're mostly pleased with the level of comfort it offers.